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The integrated stress response effector ATF4 is an obligatory metabolic activator of NRF2

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At present, the best therapeutic strategy is to maintain good glycaemic control and early screening and to provide prompt treatment when micro- and macrovascular complications are detected.73 The continuous improvement in knowledge about the molecular and progression mechanisms of diabetic angiopathy is essential for the development of newer and better pharmacological therapies, targeted not only to just maintaining normoglycaemia but also to control the essential factors that contribute to the inflammatory state of diabetes