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403,404 Similarly, CYP2J2 transgenic, CYP2C8 transgenic and sEH -/- mice each exhibited a significant attenuation of endotoxin-induced activation of NF-B signaling, cellular adhesion molecule, chemokine, and cytokine expression, and neutrophil infiltration in vivo

Studies using experimental animal models have shown that hepatic enzymes such as AST and ALT and lipid peroxidation are reduced, and glutathione levels are restored with TA (Li et al

This suggests that the changes in glutathione kinetics in the elderly group are the result of aging per se and not to their overall higher BMI

Lipid accumulation in renal cells stems from both increased lipid uptake and impaired fatty acid oxidation (57)