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doi: 10.3892/ijmm.2014.1792 201 WapenaarH.DekkerF

Nature 600 , 4041 (2021)

To establish a rapid and versatile approach to obtain D-monobodies without the need to optimize the synthesis conditions, the second binder, DAM21 , was split into two complementary segments at a loop region not involved in the ABL SH2 binding, as determined from the crystal structures of the heterochiral monobody-ABL SH2 complexes