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When supported, resilience and regulation improve

Importantly, GSH itself does not spontaneously sequester hydroperoxides since the reaction kinetics are far too slow (30 M 1 s 1 ) (Berndt et al., 2 O 2 and lipid hydroperoxides or participate in covalent modification of protein cysteine thiols depends on various enzymes that specifically bind glutathione to catalyze redox reactions (Flohe, 2 O 2 and lipid hydroperoxide detoxification are enzymatically-mediated by glutathione peroxidase (Gpx) 1 and Gpx4