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All of these tissues can be primary generators of noxious stimuli that cause the brain to perceive pain as arising from a location that is different from, or remote to, the somatic tissue from which this stimulus arises

SARS-CoV-2 may activate TLR4 in the heart and lungs causing aberrant TLR4 signaling favoring the proinflammatory MyD88-dependent (canonical) pathway instead of the alternative TRIF/TRAM-dependent anti-inflammatory and interferon pathway (Aboudounya and Heads, 2021)

Dixon et al., GST genes were shown to be strongly inducible by the key defense hormone salicylic acid (SA) (Fodor et al., 2004, 2009)

Methylation also feeds into glutathione synthesis (via the transsulfuration pathway), so methylation dysfunction can collapse GST capacity simultaneously