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Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease worldwide, now recognized as a multisystem metabolic disorder closely linked to obesity, type 2 diabetes mellitus (T2DM), and cardiovascular risk [1]

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These pentapeptide-based self-assembled hydrogels exhibit tunable morphological and mechanical properties, along with self-healing and shear-thinning characteristics, making them promising candidates for tissue engineering, injectable delivery carriers, and 3D printing applications (Figure 3a)