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Figure 1b,c show the experimental design of the glutamine MRI study and the effect of the ASCT2 inhibitor

Whilst the mechanisms of altered lipid metabolism in FRDA are not completely understood it has been suggested that reduced PPAR expression and its transcriptional regulator PGC-1, could lead to reduced breakdown of lipids, specifically PUFAs, making them more readily available to undergo lipid peroxidation (Tamarit et al., 2016