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Renal effects, including acute kidney injury, have been reported rarely in post-marketing surveillance, typically in the context of severe gastrointestinal adverse effects leading to dehydration

By 2.4 bya, in occurrence with the Great Oxidation event, ROS had been recruited into early redox signalling systems 1,11,12,13 , and thus the roles of antioxidants had expanded to include regulators of redox signalling

The field of regenerative medicine has long centered on cell-based therapies, but increasing attention is now given to bioactive molecules that regulate tissue repair