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In the present study, the activation of JNK, ERK1/2 and p38 signals was significantly increased in the EpCAM +/ + DSS group but not in the WT + DSS group, and importantly the activation of JNK and ERK1/2 was also higher in EpCAM +/ mice than WT mice (Figure 2C)

Vitamin B12 measurements From January 2016 to December 2023, a total of 84 million vitamin B12 measurements were obtained from both public and private healthcare systems in Brazil (Figure 1A)

Shapiro-Wilk test revealed the differences were normally distributed, so a paired t-test was used for further statistical analysis