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In another atherosclerosis model, ApoE / and GPx1 double knockout mice exhibited significantly increased atherosclerotic lesion development, suggesting that GPx1 may also play a role in disease progression ( Reference Lewis, Stefanovic and Pete 88 )

Perhaps, IL-4 induces epithelial remodeling by promoting the secretion of epithelial wingless/integrase 5a (Wnt5a) (133)

CSF neurosin (a protease that degrades -synuclein) levels have been found to be decreased (Wennstrm et al., 2013)

A reduction in -ketoglutarate, as reflected by lower -ketoglutarate/aconitate ratios, skews macrophages toward a proinflammatory phenotype