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Thus, the inhibitory activities are only directed against microbial proteases and not against granule proteinases, suggesting that they may act as endogenous antibiotics [90]

Several NAD+ precursor molecules were released to replace NAD+, demonstrating that NAD+ replacement is what generates the beneficial effects (25)

In general terms, prognosis is not favorable as approximately half of the patients die within the first year after diagnosed, the vast majority of which die within the first two years, and less than 5% survive for 5 years [5]

10.1371/journal.pone.0119516 86 HsiehC.-L.LinC.-H.WangH.-E.PengC.-C.PengR