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There was no known history of diabetes, thyroid disorders, renal or liver disease, or recent infections

Functional impact of a spectrum of interstitial lung abnormalities in rheumatoid arthritis

Since its inception in the early 1940s, Waddingtons concept of epigenetics took on additional meanings until encompassing the current notion of stochastic or environment-induced modifications of histone proteins or DNA without changes in the DNA sequence itself that alter the accessibility of genes to transcription factors [9]