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Both products, along with 3-deoxyglucosone (or Amadori product), serve as precursors for the formation of AGEs, which react with elements of the extracellular matrix (ECM), leading to AGE production

These include both immune-stimulating and immune-suppressing peptides, depending on the therapeutic application

In practical terms, that means far less antioxidant reserve at exactly the time when cells face more oxidative stress

Although the procedure of BBB disruption has been considered as an ideal strategy in improving the delivery to the brain tissue, there are a number of challenges and restrictions to be considered