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Group 4 (DEX + SPAE 800): Received DEX (10 mg/kg, I/P) and SPAE orally at 800 mg/kg/day ( The 400 mg/kg and 800 mg/kg body weight/day doses for Spirulina platensis aqueous extract were selected based on previous studies demonstrating safety and hepatoprotective efficacy in rodent models ( Twenty-four hours after the final treatment following the 28-day study, delivery was conducted under ketamine/xylazine anaesthesia at dosages of 7.5 and 1.0 mg/kg by intraperitoneal infusion ( The liver specimens were preserved in a 10% formalin saline solution for histological analysis

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To investigate if ABCC1 is involved in efflux of Venetoclax or AZD-4320 we treated HL-60 cells overexpressing ABCC1 with either compound and used liquid-chromatography mass-spectrometry (LC-MS) to quantify drug concentrations in cell lysates and fresh culture supernatants over time (Supplementary Fig