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Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons

Confocal Microscopy and Spectral Analysis Channel mode confocal images of BODIPY, Nile Red, and GFP fluorescence in late stage L4 animals were acquired essentially the same as previously described [21]

We then performed another in vivo experiment in which mice ( n = 10/group) were rendered diabetic (i.e., three consecutive readings above 250 mg/dL) prior to THR-123 (20 mg/kg) or saline administration

Briefly, mice bearing TSC2 -/- ELT3 xenograft tumors were treated every other day for 5 days with vehicle or rapamycin (1 mg/kg on day 1, 3, and 5) and tumors were harvested for metabolite extraction, as above, 3 h after the final treatment