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Without VIC, enzyme inactivation occurs rapidly but remains reversible [24,45]

This contrasts sharply with full-length human growth hormone, which can impair glucose tolerance and insulin sensitivity, potentially precipitating or worsening diabetes

Notably, several of the pro-inflammatory cytokines known to upregulate CD38 expression, including IL-6, interferons, TGF-, as well as SASP, are also implicated in SSc 2