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Gibon J, Barker PA (2017) Neurotrophins and proneurotrophins: focus on synaptic activity and plasticity in the brain

In general, there is still limited number of options for systemic therapy in patients with inoperable regional and distant metastases

But using the formulations of nanoparticles, the brain distribution of LENK was facilitated, with no peripheral exposure, and within the thalamus and cortex, nanoparticle localization can be observed