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10.1021/acsami.1c16737 45 JiY.HuangQ.JiaQ.YanH.ChiY.JiaY.et al (2025)

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Disclosures: Richard Kalman: Nothing to Disclose, Kristel Hunt: Nothing to Disclose, Mark Gallagher: Nothing to Disclose, Yang Yue: Nothing to Disclose, Andrzej Kosinski: Nothing to Disclose, Victor Navarro: Nothing to Disclose, Manisha Verma: Nothing to Disclose 2221 EXERCISE DURING HYPERAMMONEMIA ACTIVATES ADAPTIVE SKELETAL MUSCLE AMMONIA METABOLISM Annette Bellar 1 Avinash Kumar 2 Muaz Alsabbagh Alchirazi 1 Amy Attaway 1 Pugazhendhi Kannan 1 Saurabh Mishra 1 Nicole Welch 1 Srinivasan Dasarathy 1 , 1 Cleveland Clinic, 2 All India Institute of Medical Sciences Background: Exercise induced muscle ammoniagenesis can worsen muscle perturbations and limit beneficial responses in liver disease

For instance, in melanoma, miR-9 targeted GOT1 directly, inhibiting the expression of GOT1, which suppressed ferroptosis of melanoma cells (76)