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plantarum CLP-0611 trigger M2 macrophages to exert the anti-inflammatory function thereby initiate macrophage polarization from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype

SAE, which includes critical or life-threatening illness or death, will be documented from the time of enrolment throughout the study period

Such symptoms could be managed by psychological therapy to effectively restore immune system alterations in young adults (Pearlstein et al., 2020)

The ASL, comprising the periciliary liquid layer and the overlying mucus gel, must maintain an optimal depth and composition to facilitate effective ciliary beating and mucus transport [29]