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The cytotoxic effect is likely a result of inhibition of replication by cisplatin-DNA adducts and induction of apoptosis (Siddik, 2003)

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On the genus level, LefSe analysis of indicator OTUs showed Ilumatobacter , Peptoniphilus , Limnobacter , Mizugakiibacter , Chelatococcus , Stella , Filimonas , and Streptosporangium were associated with the treatment diet, whereas Arcobacter , Ferrovibrio , Buchnera , Chitinophaga , Stenotrophobacter , Solimonadaceae , Polycyclovorans , Rhodococcus , Ramlibacter , and Azohydromonas were associated with the control diet

In tumor-adjacent breast tissue, the levels of 4-OHE 1 (E 2 ) were almost four-times higher than those in breast tissue from women without breast cancer 36