The management of AEs associated with FGFR inhibitors in the clinical trial setting has been reviewed recently (Kommalapati et al., 2021
The most common any-grade imAE categories (2.0% of participants) in the STRIDE arm were endocrine events (16.5%, including hyperthyroid events, hypophysitis, and hypothyroid events), hepatic events (7.5%), diarrhea/colitis (5.9%), dermatitis/rash (4.9%), and pancreatic events (2.3%) (Supplemental Table S2, Hepatic events and endocrine events were the most common any-grade imAE categories (2.0% of participants) in the durvalumab monotherapy arm, occurring in 6.7% and 6.2% of participants, respectively (Supplemental Table S2, Across the STRIDE and durvalumab arms, the proportions of participants who had a hepatic imAE that resolved, or led to discontinuation of study drug, or did not resolve were similar (Supplemental Table S3, The most common any-grade imAEs (2.0% of participants) in the STRIDE arm were hypothyroidism (10.1%), hyperthyroidism (4.6%), diarrhea (4.4%), hepatitis (2.6%), rash (2.3%), and alanine aminotransferase increase (2.1%) (Figure 2)
Hormonal Disorder When women suffer from any hormonal disorders it can lead to enlarged ovaries with cysts
Notably, systolic function remains unchanged (Pelleymounter et al., 1995) rather than cardiac dysfunction as ob/ob mice do not display other overt HF symptoms such as pulmonary congestion before their premature death
