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Though the phenomenon of tear-film breakup was described in the early 1900s, the bulk of reports on TFBUT as a clinical entity emerged in the late 1960s and early 1970s, defining the measurement as the time from the last complete blink to the formation of the first dry spot.7 In 1975, a report was published demonstrating the effects of a new tear substitute (Tears Naturale, Alcon) on TFBUT, lasting 90 minutes post-instillation.8 The authors also theorized that a longer TFBUT corresponded to enhanced tear-film stability, a notion that has persisted over the last three decades

Activation of cAMP signaling in response to alpha-phellandrene promotes vascular endothelial growth factor levels and proliferation in human dermal papilla cells