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A recent endoscopy shows a gastric ulcer with active bleeding

50 Although transient DNA damage was also observed after moderate APAP overdose, it was followed by prompt activation of DNA repair pathways, which was missing after severe APAP overdose

In addition, even though taking into account potential confounders is more important than the sample size by itself as aforementioned, our sample size may have limited the power to detect differences in patient-centered outcomes, particularly endoscopic remission. Several strengths have to be underlined such as the inclusion of consecutive patients with daily practice standardized evaluation and high-quality collected data anticipating the future use for real-world evidence research and methodological expertise in comparing real-world data [7,9,25]

First, the simulation model containing the activating center (~400 atoms) of TYR was constructed (Supplementary Fig