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One study found that blood levels of cytokines, including IL-6 and TNF-, were significantly higher in depressed patients than in healthy controls (202), and that these pro-inflammatory cytokines, especially IL-6, IL-1, and TNF-, promote the production of Th17, which has been implicated in depression and other CNS disorders closely associated with them (203)

Safety, tolerability, and pharmacokinetics of casimersen in patients with duchenne muscular dystrophy amenable to exon 45 skipping: a randomized, double-blind, placebo-controlled, dose-titration trial

Translational investigation of the therapeutic potential of cannabidiol (CBD): toward a new age

Retatrutide is being studied as a triple-agonist acting on GLP-1, GIP, and glucagon , while semaglutide and tirzepatide act on fewer pathways.