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10.1016/j.biopha.2022.114142 196 HuJ.LiH.WangX.ChengH.ZhuG.YangS

Pharmacological inhibition of MT1-MMP improves aging- and obese-associated glucose homeostasis To further investigate the therapeutic potential of targeting MT1-MMP in the management of insulin resistance, aged mice on chow diet were administrated with 3A2, a well-characterized anti-MT1-MMP monoclonal antibody with remarkable neutralizing properties 16,17