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Augmentation of neutrophil numbers and function by adding G- CSF, inhibiting CXCR4 and blocking CD47-SIRP interactions may be a therapeutic approach to enhance the function of neutrophils in infections (Nmeth et al., 2020)

Stoyanovsky DA, Tyurina YY, Shrivastava I, Bahar I, Tyurin VA, Protchenko O et al (2019) Iron catalysis of lipid peroxidation in ferroptosis: regulated enzymatic or random free radical reaction

In cardiometabolic settings such as obesity, metabolic dysfunction-associated steatotic liver disease, and atherosclerosis, chronic exposure to excess free fatty acids and toxic lipid species, such as ceramides, disrupts organelle integrity, impairs efferocytosis, and skews macrophages toward pro-inflammatory phenotypes