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Moreover, polyphenols reduce excessive nitric oxide (NO) generation linked to inflammation and tissue damage by modulating mitogen-activated protein kinases (MAPKs) and inhibiting the manifestation of inducible nitric oxide synthase (iNOS) (Yahfoufi et al., 2018)

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Challenges and future aspects Challenges in the experimental tools to study the exact mechanism of HIV-1-related factors on microglial activation Experimental model limitations: many current models fail to replicate the complex microenvironment of the CNS, which often results in incomplete or potentially misleading interpretations of activation mechanisms

This key issue is absolutely required, but quite challenging, since these two dimensions correspond to traditionaly different epistemic fields