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The largest trial involving DSIP to date, which included a total of 107 volunteers, reported that the peptide was generally well-tolerated with mostly minor side effects, which included [8]: Low blood pressure Increased sweating Headache Nausea Vertigo Considering that the drop in blood pressure was reported as moderate to severe in some patients, researchers should consider hypotension as a potentially exclusionary criterion for DSIP research

Indeed, while in rats exposed to alcohol without BPC 157 administration, more pronounced edema of stroma and striated muscle was seen, in the peptide-treated animals only mild reactive changes on the surface epithelium and scarce, unevenly distributed accumulations of polymorphonuclear inflammatory cells on the muscle were noticed

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