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The recommended selumetinib dose based on body surface area is 25 mg/m 2 orally twice daily until patients experience disease progression or unacceptable toxicity

67,68 These mutations may have different origins, including pre-existing somatic mutations in original cells used for reprogramming, 69,70,71,72,73 the reprogramming process to generate hiPSCs, 71,74,75,76 passaging, 71,77 and in vitro differentiation process 78 to produce transplantable cell source

doi: 10.1038/s41419-023-06045-y 92 MurphyMP

A response surface methodology was employed according to the central composite design for the lipid extraction and subsequent conversion to the biodiesel under supercritical methanol condition (Shirazi et al