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Description

Lactylation development and its mechanisms Development of lysine lactylation PTMs alter the biochemical properties of specific amino acid residues in proteins, which changes their functions and regulates gene expression

Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration

H.PoolmanB.van SinderenD

doi: 10.1016/j.jbspin.2025.105892 Summary Keywords NLRP3 inflammasome, oxidative stress, programmed cell death, sodium urate crystal, soluble uric acid Citation Yang Q, Xu Y, Zhang J, Xiao N, Lu H, Chen B, Yang B, Xie Z and Li Z (2026) From soluble uric acid to sodium urate crystal: immune metabolic inflammation driven by uric acid morphological transformation and mechanism-oriented therapy