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Indeed, after introduction of HAART to treat HIV-1 infection, it quickly became apparent that mitochondrial toxicity is a major reason for antiretroviral-related adverse events (Brinkman et al., 1998)

Dynamic differences in dietary polyunsaturated fatty acid metabolism in sputum of COPD patients and controls

While this effect was observed in a viral model, it suggests that loss of antioxidant capacity may confer an advantage in tissue environments, with implications for solid tumors

In terms of the use of probiotic therapy to delay aging, no clinical trials with large sample size have been conducted, and sufficient evidence-based proof remains lacking