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Notably, kidney proximal tubular cells are particularly sensitive to hypoxic injury, and the degree of tubular damage is a key determinant of kidney disease prognosis [22]

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Therefore, multiomics-assisted agriculture crop improvement would be a promising area of research along will open a new avenue of HMs-tolerant crop production for smart and sustainable plant production for global food security

Ethics approval and consent to participate Human tissue and animal specimens were not involved in this study