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15 Key Inflammatory Mediators Tumour necrosis factor-a (TNF-) TNF- is one of the major pro-inflammatory cytokines that is significantly increased in diabetic wounds Overexpression of TNF- inhibits fibroblast proliferation and collagen synthesis and stimulates apoptosis of endothelial cells and keratinocyte

Blood was collected by exsanguination into heparinized tubes containing 200 l of 1 mM bathophenanthroline disulfonic acid (BPDS)

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Liver diseases cause over two million deaths each year, underscoring the need for new hepatoprotective agents