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Interestingly, besides 2-HNA, pyrazinoic acid was also found to sensitize OVCAR-5 cells to FK866 by reducing viability and blunting NAD + levels inside the cells [91]

Nature 583 (7816), 441446

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Several mechanisms are associated with the neuroprotective effect of NMNATs, including the suppression of ROS production, mitochondrial stabilization [120], promotion of the clearance of hyperphosphorylated Tau protein oligomers [121], autophagic clearance of amyloid plaques in Alzheimers disease models [122], and reduced accumulation of mutant Huntingtin (Htt) aggregation [123]