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Furthermore, sodium butyrate supplementation (45 g/day) improved growth rates, ADG, feed conversion efficiency, and serum antioxidant markers, including increased GSH-Px activity and decreased MDA levels [50,51,52]

The specific genera that increased in the PSO rats were Lachnospiraceae_NK4A136_group , Bacteroides , Clostridia_vadinBB60 , and Roseburia , while Alloprevotella , Muribaculaceae , and Alistipes , Prevotellaceae_UCG-001 , Rikenellaceae_RC9_gut , and Clostridia_UCG-014 decreased significantly ( Figure 3F )

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This led him to suggest the existence of accessory factors in food that were crucial for life processes, in addition to the known major nutrients