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doi: 10.1038/labinvest.2014.98 51 PalmaFRGantnerBNSakiyamaMJKayzukaCShuklaSLacchiniRet al

ROS and intracellular iron accumulation are important processes that trigger the mitogen-activated protein kinase (MAPK) pathway, decrease intracellular glutathione (GSH) depletion, and limit cystine absorption