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Although in this yeast no co-regulation has been found between GSH biosynthesis genes and iron metabolism, the involvement of glutathione in maturation Fe/S proteins has been demonstrated ( GSH1 and GSH2 genes from S.bacillaris strains displayed 26 and 20 insertions or deletions (INDELs) respectively when compared to S.cerevisiae EC1118, but none were located in the GSH2 regions of substrate binding (Table 2)

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In the era of first-line genomics ATM variants are frequently being identified and diagnostic biomarkers (AFP, NfL, cellular and humoral immunodeficiency, 5-mC) can assist in the validation of pathogenicity

Across preclinical work, the most consistent signals are Remodeling of the extracellular matrix, including collagen and elastin pathways Anti inflammatory actions and modulation of oxidative stress markers Support for repair processes in tissue and skin models Human clinical data exist, but they are limited in size and quality