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In a single-center, randomized, double-blind, placebo-controlled trial conducted at the Emergency Department of a hospital in Brazil, 140 patients with severe COVID-19 infection and oxyhemoglobin saturation of less than 94% or respiratory rate higher than 24 breaths/minute were randomized to receive N-acetylcysteine 21,000 mg (approximately 300 mg/kg) for 20 hours or dextrose 5% (placebo)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 145.Petrella C., Carito V., Carere C., Ferraguti G., Ciafr S., Natella F., Bello C., Greco A., Ralli M., Mancinelli R., et al

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