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A methodical rotation plan that leaves the same patch unused for 3 to 4 weeks, combined with technique adjustments like injecting over 5 to 10 seconds and holding the needle for 5 seconds, substantially reduces repeated-site irritation

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Ha, J., Yu, J., Lee, J., & Kim, H

Analysis of effectiveness of treatment (main outcome) at the three monitoring points Intention-to-treat and per-protocol analyses will both be performed, as is recommended for non-inferiority studies [38]