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Suitable for long-term use: It supports ongoing pigmentation management while fitting easily into a daily skin care routine Cost-effective alternative: It offers a practical option for those looking to reduce pigmentation without frequent cosmetic treatments

Their mobility and bioavailability are a significant concern globally owing to plant uptake and increased human exposure to these HMs by eating contaminated foods (Mapodzeke et al., 2021)

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39 Although various signaling pathways involve in the regulating of hair follicle generation and hair growth, such as Keap1-Nrf2 pathway, 40 Akt--Catenin pathway, 40 NF-B 29 and MAPK, 16,41,42 et al