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A better understanding of the molecular basis responsible for considerable deterioration of lysosomal function in the ageing brain requires the development of more cell-specific probes for this incipient pathobiology applied to in vivo model systems, rather than cultured cells, to appreciate the extent of its synergies with disease factors and what interventions may be effective to preserve lysosome health in normal ageing

Breton G, Mendoza P, Hgglf T, Oliveira TY, Schaefer-Babajew D, Gaebler C et al

The original paper is in Mandarin and you can access it here (paywall): #Type2Diabetes #DiabetesResearch #Obesity #GLP1 #Semaglutide #Dorzagliatin #MetabolicHealth #HuaMedicine To view or add a comment, sign in A newly published peer-reviewed scientific paper from China adds to the growing body of evidence around the benefits that dorzagliatin (GKA) in combination with the popular semaglutide (GLP-1RA) delivers superior glycemic control, weight reduction, and islet cell function improvement when compared with semaglutide monotherapy in obese patients with Type 2 diabetes mellitus (T2DM), with a comparable safety profile

A drip will not replace sleep, a balanced diet or treatment of an underlying illness