1 Several antidepressant medications are known to increase systemic levels of serotonin, including monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), some opioids, antihistamines, serotonin-releasing illicit drugs, and over-the-counter herbal medications 1 (Figure 1)

Common Side Effects Experienced by some users Injection site reactions Temporary redness, swelling, or mild pain at injection site Management: Rotate injection sites, ensure proper technique, apply ice if needed Flushing or warmth Brief feeling of warmth or facial flushing shortly after injection Management: Usually resolves within 15-30 minutes, no treatment needed Water retention Mild fluid retention, especially in first few weeks Management: Usually temporary, reduce sodium intake if bothersome Increased appetite GH stimulation can increase hunger Management: Plan meals accordingly, can be beneficial for muscle-building goals Less Common Tingling or numbness Headache These typically resolve with continued use or dose adjustment
KEGG pathway analysis ( b )
An initial consultation is required before starting BPC-157 therapy