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(PubMed) Lefer DJ

8 One proposed mechanism underlying this phenomenon is the competitive utilization of CYP 2E1 in herbal drug metabolism that would decrease APAPs conversion into its toxic metabolites, such as NAPQI

2008 Nov;38(10):1976

These mechanisms include enhanced metabolic activity of drug-detoxifying proteins such as glutathione-S-transferase, increased efflux of the drug partially caused by upregulation of ATP-binding cassette (ABC) transporters, changes in microtubule formation and kinetics due to overexpression of III-tubulin, and mutations in tumor suppressor genes [101]