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Abbreviations A: Adenine ABTS: 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) Ac: Acetyl Bu 4 NBr: Tetrabutyl ammonium bromide C: cytosine DIAD: Diisopropyl azodicarboxylate DMF: Dimethylformamide DPPH: 2,2-Diphenyl-1-picrylhydrazyl G: Guanine HFIP: Hexafluoro isopropanol HSAc: Thioacetic acid MeOH: Methanol MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5- (diphenyltetrazolium bromide) NaOMe: Sodium methylate PPh 3 : Triphenyl phosphine TFA: Trifluoroacetic acid THF: Tetrahydrofuran TLC: Thin layer chromatography Trt: Triphenylmethyl TrtCl: Triphenylmethyl chlorid Ts: p -toluenesulfonyl TsCl: p -toluenesulfonyl chloride TsOH: p -toluenesulfonic acid U: Uridine References Gadalla, M

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Researchers should implement fasting glucose and HbA1c monitoring at minimum every 8 weeks during extended protocols

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