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Responsible interpretation requires acknowledging both the strong mechanistic research and the current lack of large-scale human clinical trials for systemic uses

Research records should document the lot number, reconstitution date, storage temperature, and usage window for each batch worked with

In AD models, it improved memory even when given late, presumably by enhancing histone acetylation and BDNF expression [262]

AIF is also critical for DNA damage and liver injury due to its involvement in DNA fragmentation [111], a fact highlighted by the fact that AIF-deficient mice have lower DNA damage and liver injury after APAP [112]