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Elesclomol is widely recognized to induce copper overdose and cell death (139), by acting as a copper ion carrier with a hydrophilic pore in its centre, to which Cu2+ ions can bind easily, facilitating copper entry into cells, thus increasing the intracellular copper concentration (140), and this, in-turn increases ROS levels, triggering oxidative stress (141) and ultimately cell death

Large conformational dynamics in band 3 protein: Significance for erythrocyte senescence signalling

To further characterize compound engagement of TGR in ex vivo worms using an orthogonal assay, inhibition of TGR activity in newly transformed schistosomula (NTS, skin-stage worms) was assessed using a TrxR-selective fluorescent probe 43,44 , TRFS-Green

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