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Notably, air pollution and pesticide exposure resulting from urbanization are significantly associated with spatial clustering of childhood IBD incidence [236,237,238], Furthermore, the effects on barrier function and immune regulation explain the rising incidence of IBD in industrialized regions [239]

The 102 CUMS-enriched KOs were typically involved in the KEGG categories of membrane transport, carbohydrate metabolism, and signal transduction (Fig

Environ Health Perspect (2003) 111(11):142938