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Each test has varying accuracy and scope for detecting synthetic cannabinoids like HHC, with urine and hair tests offering the broadest windows for detection

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Therefore, a possible interpretation for these findings is that the downregulation of both UCP3 and ANT might be a compensatory mechanism to maintain the proton-motive force and ATP synthesis in a condition where the respiratory complexes protein abundance becomes critically low and chronically elevated levels of 4-HNE or repeated cigarette smoke exposure would otherwise continuously lessen the mitochondrial membrane potential and compromise intracellular ATP levels

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