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In this case, the function of Hb is disturbed, the oxygen supply decreases and finally, hypoxia increases

Understanding how altered BDNF-TrkB signaling, particularly in iSPNs, might lead to early dopamine dysfunction in Huntington's disease could provide targets for potential preventative therapy

The loss of insulin sensitivity of hippocampal CA1 pyramidal neurons can subsequently cause long-term Ca 2+ -dependent afterhyperpolarizations (AHPs), which can produce significant cognitive and memory impairment in the short term and throughout life, contributing to depression (122, 123)

While this form of treatment is generally well-tolerated and can significantly improve quality of life, it's not uncommon to experience a few mild side effects afterward