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Couillard C, Pomerleau S, Ruel G, Archer WR, Bergeron J, Couture P, et al

Research progress and applications of multivalent, multispecific and modified nanobodies for disease treatment

Abbreviations RA: rheumatoid arthritis RF: rheumatoid factor ACPA: anti-citrullinated protein antibodies HLA: human leukocyte antigen SE: shared epitope STAT4: signal transducer and activator of transcription 4 IL: interleukin NK: natural killer IFN- : interferon- Th: T helper CTLA-4: T-lymphocyte associated antigen-4 IRF5: IFN regulatory factor 5 TNF- : tumor necrosis factor- DCs: dendritic cells MMPs: matrix metalloproteinases CVD: cardiovascular diseases HAQ: Health Assessment Questionnaire T2DM: type 2 diabetes mellitus TLR4: Toll-like receptor 4 NMR: nuclear magnetic resonance spectroscopy MS: mass spectrometry PI(3)K: phosphatidylinositol- 3-OH kinase mTOR: mechanistic target of rapamycin MetS: metabolic syndrome IR: insulin resistence SF36: 36-item Short Form Health Survey WAT: white adipose tissue PBEF: pre-B-cell colony enhancing factor NAMPT: nicotinamide phosphoribosyltransferase BAFF: B-cell activating factor PsA: psoriatic arthritis ED: endothelial dysfunction ROS: reactive oxygen species DAS: disease activity score NO: nitric oxide NF- B: nuclear factor B EPCs: endothelial progenitor cells FMD: flow-mediated dilation ADMA: asymmetric dimethylarginine NOS: NO synthase HOMA: Homeostasis Model Assessment BNP: natriuretic peptide IMT: intima media thickness DMARDs: disease-modifying antirheumatic drugs MTX: methotrexate PPAR: peroxisome proliferator-activated receptor

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